English

New insights into the interaction between femtosecond laser and living tissue

1216
2024-06-07 14:10:38
See translation

The N-linear optical microscope has completely changed our ability to observe and understand complex biological processes. However, light can also harm organisms. However, little is known about the mechanisms behind the irreversible disturbances of strong light on cellular processes.

To address this gap, the research teams of Hanieh Fattahi and Daniel Wehner from the Max Planck Institute for Photoscience (MPL), as well as Max Planck Zentrum f ü r Physik und Medizin, collaborated to determine the conditions under which strong pulsed lasers can be used in the body without damaging the organism.

The international team based in Erlangen used vertebrate zebrafish to investigate the mechanism of deep tissue light damage triggered by femtosecond excitation pulses at the cellular level. The research results have been published in the Journal of Communication Physics.

The first author of this publication, Dr. Soyeon Jun from the MPL "Femtosecond Field Mirror" group led by Fattahi, explained, "We have demonstrated that when the central nervous system (CNS) of zebrafish is irradiated with 1030 nm femtosecond pulses, it suddenly occurs at the extreme peak intensity required for low-density plasma formation.".

As long as the peak intensity is below the low plasma density threshold, this allows for non-invasive increase in imaging residence time and photon flux during 1030 nm irradiation. This is crucial for nonlinear unlabeled microscopes.

"These findings have greatly promoted the advancement of deep tissue imaging technology and innovative microscopy techniques, such as femtosecond field microscopy, which is currently being developed in my group. This technology can capture high spatial resolution, unlabeled images with attosecond time resolution," Fattahi said.

"Our research findings not only highlight the value of collaboration in the fields of physics and biology, but also pave the way for in vivo applications to achieve precise manipulation of the central nervous system based on light," added Wehner, head of the Neuroregeneration Research Group.

Source: Laser Net

Related Recommendations
  • The new method can maintain beam quality while significantly improving the power of fiber lasers

    The new discovery by optical scientists has brought new vitality to fiber lasers. This innovative method significantly improves the power of lasers without reducing beam quality, and will become an important defense technology for future low-cost drones and remote sensing.The research teams from the University of South Australia, the University of Adelaide, and Yale University have demonstrated ne...

    2023-12-22
    See translation
  • Yangtze Welcomes 8th Overseas Production Site

    On August 8, local time, Jalisco, Mexico welcomed the grand opening of Yangtze Optics Mexico Cable S.A. de C.V., marking the eighth overseas production base of Yangtze Optical Fiber & Cable Co. ("Yangtze Fiber Optics") has successfully set up its eighth overseas production base in its 36-year development history, further advancing its internationalization strategy blueprint. Today, we are pr...

    2024-08-14
    See translation
  • Scientists simulate the conditions that allow photons to collide with photons by using lasers

    As far as quantum physics is concerned, one of the most striking predictions is that matter can be produced entirely from light (i.e., photons). Pulsars are an example of an object capable of achieving this feat.In a recent study reported in the journal Physical Review Letters, a research team led by scientists at Osaka University simulated the conditions that allow photons to collide with photons...

    2023-08-11
    See translation
  • Harvard University and University of Vienna invented tunable laser chips

    Researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) and Vienna University of Technology (TU Wien) have invented a new type of tunable semiconductor laser that shows smooth, reliable, wide-range wavelength tuning in a simple, chip-sized design.Tunable lasers are integral to many technologies, from high-speed telecommunications to medical diagnostics to safet...

    07-16
    See translation
  • Toshiba has developed the world's highest precision 99.9% LiDAR technology

    Recently, Toshiba announced that in the field of LiDAR lidar for distance measurement, it has developed a technology that can track vehicles, people, and other objects with 99.9% accuracy, achieving the world's highest accuracy. And only using LiDAR to collect data can achieve 98.9% object recognition.In addition, the detection distance in rainstorm and dense fog environments has been increased by...

    2023-10-06
    See translation